Insight into the ethnopharmacology, phytochemistry, pharmacology of Launaea taraxacifolia (Willd) amin ex c. jeffrey as an underutilized vegetable from nigeria: A review
Keywords:
Launaea taraxacifolia, drug-herb, phytochemistry, ethnomedicinal
Abstract
Launaea taraxacifolia (Willd) is a perennial herb, commonly known as wild lettuce, assumed the position of wild and underutilized. It is common in Asia, North America, Europe and North Africa. Various parts of L. taraxacifolia have ethnomedicinal importance as they are employed against various ailments and diseases in humans and its traditionally use in ruminant animals. Arguments on its family is presented in this study, so far only five compounds were identified i.e. caffeic acid (1), chlorogenic acid (2), ellagic acid (3), quercetin (4) and kaempferol (5), from this neglected vegetable and an extensive range of pharmacological effects such as antioxidant, antidiabetic and hypolipidemic, antibacterial, antimalarial,
anticancer effects and drug-herb interaction of this medicinal plant with recombinant human enzymes i.e. CYP1A2, CYP2C9 and CYP3A4 was stated in this review. This study was carried out with a reason to highlight its importance and discusses its ethnomedicinal, phytochemical, pharmacological, toxicological and states its relevance beyond conventional nutritional gains. Furthermore, this review reiterates the needs to isolate constituents and carry out clinical studies to justify the scientific efficacy accrues to this medicinal plant from traditional uses and give it the due recognition as therapeutic supplement.
References
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Adetutu, A., Olorunnisola, S. O., Owoade, A. O., Adegbola, P. 2016. Inhibition of in Vivo Growth of Plasmodium berghei by Launaea taraxacifolia and Amaranthus viridis in Mice. Malaria Research and Treatment. Article ID 9248024.
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Adewale, A., Olubukola, S.O., Abiodun, O.O., Peter, A. 2016. Inhibition of in Vivo Growth of Plasmodium berghei by Launaea taraxacifolia and Amaranthus viridis in Mice. Malaria Research and Treatment, Article ID 9248024.
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Ahouansou, C.A., Fagbohoun, L., Sèdami, M. F., Alban, H.G., Siméon, K., Fernand G.A. 2017. Inhibition Effects of Elaeis oleifera (Arecaceae) and Launaea taraxacifolia (Asteraceae) on Two Genotypes of Anopheles gambiae Larvae. International. Journal of. Current. Research. Bioscience and. Plant Biology, 4, 39-46.
Amujoyegbe, O.O., Idu, M., Agbedahunsi, J.M., Erhabor, J.O. 2016. Ethnomedicinal Survey of medicinal plants used in the management of sickle cell disorder in Southern Nigeria. Journal of Ethnopharmacology, 185, 347-360.
Appiah-Opong, R., Commandeur, J.N.M., van Vugt-Lussenburg, B., Vermeulen, N. P. E. 2007. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology, 235, 83–91.
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Bello, O.M., Zaki, A.A., Khan, I.S., Fasinu, P.S., Ali, Z., Khan, I.A., Usman, L.A., Oguntoye, O.S. 2017. Assessment of selected medicinal plants indigenous to West Africa for antiprotozoal activity. South African Journal of Botany 113, 1200-211.
Borokinia B.F., Labunmi L. 2017. In vitro investigation of antioxidant activities of Launea taraxacifolia and Crassocephalum rubens. International Journal of Food Studies, 6: 82-94.
Burkill, H.M. 1985. The useful plants of West Tropical Africa. 2nd Edition. Volume 1, Families A–D. Royal Botanic Gardens, Kew, United Kingdom. Pp 960.
Christensen, C.B., Soelberg, J., Stensvold, C.R., Jäger, A.K. 2015. Activity of medicinal plants from Ghana against the parasitic gut protist Blastocystis Charlotte Bremer. Journal of Ethnopharmacology, 174, 569–575.
Cronquist, A. 1981. An Integrated System of Classification of Flowering Plants, Columbia Univ. Press, New York, 1020-1028.
Dairo, J.O., Ukpanukpong, R.U., Uyabeme R.N. 2015. Phytochemical screening, proximate analysis and acute toxicity study of Launaea Taraxacifolia ethanolic extract on albino rats. The International Journal of Science and Technology, 3, 199-202
Dansi, A., Vodouh`e, R., Azokpota, P., Yedomonhan, H., Assogba, P., Adjatin, A., Loko, Y.L., Dossou-Aminon, I., Akpagana, K. 2012. Diversity of the neglected and underutilized crop species of importance in Benin. The Scientific World Journal, Article ID 932947.
Dickson, R.A., Annan, K., Fleischer, T.C., Amponsah, I.K., Nsiah, K., Oteng, J.A. 2012. Phytochemical investigations and nutritive potential of eight selected plants from Ghana. Journal of Pharmacy and Nutrition Sciences, 2, 172-177.
Funk, V.A. 2005. Everywhere but Antarctica: Using a Super-tree to understand the diversity and distribution of the Compositae. Biologiske Skrifter, 55, 343-374.
Ganong, W.F. 2003. Circulating body fluids: Review of Medical Physiology. 21st Edition. Typo Press, Lebanon. Gbadamosi, I.T., Okolosi, O. 2013. Botanical galactogogues: nutritional values and
therapeutic potentials. Journal of Applied Biosciences, 61, 4460– 4469.
Koukoui, O., Agbangnan, P., Boucherie, S., Yovo, M., Nusse, O., Combettes, L., Sohounhloué, D. 2015. Phytochemical study and evaluation of cytotoxicity, antioxidant and hypolipidemic properties of Launaea taraxacifolia leaves extracts on cell lines HepG2 and PLB98. American Journal of Plant Sciences, 6, 1768-1779.
Koukoui, O., Senou, M., Agbangnan, P., Seton, S., Koumayo, F., Azonbakin, S., Adjagba, M., Laleye, A., Sezan A. 2017. Effective in Vivo cholesterol and triglycerides lowering activities of hydroethanolic extract of Launaea Taraxacifolia leaves. International Journal of Pharmaceutical Sciences and Research, 8, 2040-2047.
Kpodar, M.S., Lawson-Evi, P., Bakoma, B., Eklu-Gadegbeku, K., Agbonon, A., Aklikokou, K., Gbeassor M. 2015. Ethnopharmacological survey of plants used in the treatment of diabetes mellitus in south of Togo (Maritime Region). Journal of Herbal Medicine, 5, 147–152.
Lydia. E.K. 2012. Safety Assessment of the ethanolic leaf extract of Launaea Taraxacifolia (Willd) of the family asteraceae in rodents. M. Sc. Thesis, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana, 110.
Ladan, M.J., Bilbis, L.S., Lawal, M. 1996. Nutrient composition of some green leafy vegetables consumed in Sokoto. Nigeria. Journal of. Basic Applied Science, 5, 39-44
Louis, F., Ayidé, A.C., Fagla Sèdami, M.R., Jules, T.M., Siméon, K., Fernand, G.A. 2015. Phytochemical analysis of Launaea taraxacifolia (Asteraceae) on Anopheles gambiae, a malaria vector. Photon Journal 23 (3), 123-127
Magbagbeola, J.A.O., Adetoso, J.A., Owolabi, O.A. 2010. Neglected and underutilized species (NUS): a panacea for community focused development to poverty alleviation/poverty reduction in Nigeria. Journal of Economics and International Finance, 2, 208–211.
Martin, J., Registrar, C. P., Fay, M. 2001. Cytochrome P450 drug interactions: Are they clinically relevant. Drug Safety,. 26, 13–21.
Mccrea, J., Cribb, A., Rushmore, T., Osborne, B., Gillen, L., Lo, M., Waldman, S., Bjornsson, T., Spielberg, S., Goldberg, M.R. 1999. Phenotypic and genotypic investigations of a healthy volunteer deficient in the conversion of losartan to its active metabolite E-3174. Clinical Pharmacology Therapy, 65, 348–352.
Nishio, S., Watanabe, H., Kosuge, K., Uchida, S., Hayashi, H., Ohashi, K. 2005. Interaction between amlodipine and simvastatin in patients with hypercholesterolemia and hypertension. Hypertension Research, 28, 223–227.
Obi, R.K, Iroagba, I.I., Ojiako, O.A. 2006. Virucidal potential of some edible Nigerian vegetables. African Journal of Biotechnology, 5, 1785-1788.
Olugbenga, D.J., Undigweundeye, U.R., Ngozi, U.R. 2015. Phytochemical screening, proximate analysis and acute toxicity study of Launea taraxacifolia ethanolic extract on albino rats. Interrnational Journal of Science and Technology, 3, 199 – 202.
Omédine, K., Pascal, A., Sylviane, B., Mahudro, Y., Oliver, N., Laurent, C., Dominique, S. 2015. Phytochemical Study and Evaluation of Cytotoxicity, Antioxidant and Hypolipidemic Properties of Launaea taraxacifolia Leaves Extracts on Cell Lines HepG2 and PLB985. American Journal of Plant Sciences, 6, 1768-1779.
Owoeye, O., Arinola, G.O. 2017. A Vegetable, Launaea taraxacifolia, Mitigated mercuric chloride alteration of the microanatomy of rat brain. Journal of Dietary Supplements, 4, 613-625.
Owoeye, O., Femi – Akinlosotu, M., Adejuwon, S.A. 2015. Launaea taraxacifolia acqueous extract attenuates cisplatin – induces neurotoxicity by decreasing oxidative stress and neurol cell death in rats. Archives of Basic and Applied Medicine, 3, 71 – 78.
Owoeye, O., Gbadamosi, I.T., Alia, A. E., Okolosi, O. 2012. In – vitro antimicrobial activities and nutritional assessment of roots of ten Nigerian vegetables. New York Science Journal, 5, 234 – 240.
Owoeye, O., Onwuka, S. K. 2016. Lead toxicity. Effect of Launaea taraxacifolia on the histological and oxidative alterations in rat region II cornu ammonis and cerebellum. Anatomy Journal for Africa, 5, 783 – 7S94.
Park, B.K., Pirmohamed, M., Kitteringham, N.R. 1995. The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacology and Therapeutics, 68, 385-424.
Ruffina A.N., Chukwuma O.M., Akachukwu E.E., Iroka F.C. 2016. Phytochemical analysis and antibacterial activity of Launaea taraxacifolia ethanolic leave extract. Scholar Academia Journal of Bioscience, 4, 193-196.
Salisu G., Titilola F., Okpuzor, J., Jaja, S.I. 2016. Antilipidaemic studies of aqueous extracts of five selected nigerian local edible vegetables in experimentallyinduced myocardial infarction in male wistar albino rats. Organization for women in science for the developing world (OWSD). Fifth General Assembly and International Conference on Women in Science and Technology for the
Developing World, Kuwait.
Sanoussi, F., Ahissou, H., Dansi, M., Hounkonnou, B., Agre, P., Dansi, A. 2015. Ethnobotanical investigation of three traditional leafy vegetables [Alternanthera sessilis(L.) DC. Bidens pilosa L. Launaea taraxacifolia Willd.] widely consumed in southern and central Benin. Journal of Biological and Environment Science, 6 , 187-198.
Seedat, Y.K., Rayner, B.L. 2011. South african hypertension guideline 2011. South. Africa. Medicine. Journal, 102, 57–88.
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Published
2018-11-20
How to Cite
Bello, Oluwasesan, Ogbesejana Abiodun, and Stephen Oguntoye. 2018. “Insight into the Ethnopharmacology, Phytochemistry, Pharmacology of Launaea Taraxacifolia (Willd) Amin Ex C. Jeffrey As an Underutilized Vegetable from Nigeria: A Review”. The Annals of the University Dunarea De Jos of Galati. Fascicle VI - Food Technology 42 (2), 137-52. https://www.gup.ugal.ro/ugaljournals/index.php/food/article/view/1151.
Issue
Section
REVIEW ARTICLES
