Improved solubilization of curcumin with a microemulsification formulation

  • Romică Cretu “Dunărea de Jos” University of Galati, Faculty of Sciences, Chemistry, Physic and Environment Department
  • Cristian Dima S.C. Saltempo S.R.L., Basarabiei
  • Gabriela Bahrim “Dunărea de Jos“ University of Galati, Faculty of Food Science and Engineering
  • Ştefan Dima “Dunărea de Jos” University of Galati, Faculty of Sciences, Chemistry, Physic and Environment Department
Keywords: self microemulsifying oil formulation, cosolvents, surfactants, quaternary phase diagrams

Abstract

Due to the large number of bioactive substances, with low and very low solubility in water, new and improved investigation methods were developed. Researches in this area have shown that lipid systems in lipophilic substances formulation increase their bioavailability and prevent or reduce the toxicological risk because most of the components involved in the formulation are of natural origin, with a structure compatible with biological membranes components. Among the lipid systems used in the leaching, transport and release of lipophilic substances there are: liposomes, solid lipid nanoparticles, double and single emulsions, autoemulsionante and auto-microemulsionante lipid systems. The last are the subject of the present research and meet specialists in concern for the harmonization of cost-benefit-risk in order to improve population health. Curcumin [(1E, 6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5- dione] is a yellow pigment derived from the rhizome of the plant Curcuma Longa with phenol groups and conjugated double bounds which is unstable at light and basic pH, degrading within 30 minutes. The aim of this study is curcumin solubilization used as alimentary dye in automicroemulsionante systems. Dye/oil/surfactant/cosurfactant mixing ratio was made, based on quaternary phase diagrams. Mesofazice structures were revealed by conductivity and viscosimetric analysis. A curcumin solubilization system in aqueous medium was obtained. On the other hand, this paper studies the colour evolution of these automicroemulsionante systems comparing with hexane dye solution. The use of the chromatic attributes L*, a* and b* and L*, C* and hab,
suggested by the Commission Internationale de l’Eclairage (CIE) (i.e., the CIELAB system), obtained from direct transmitance measurements, which made it possible to follow the evolution of colour.

Published
2011-11-23
How to Cite
Cretu, Romică, Cristian Dima, Gabriela Bahrim, and Ştefan Dima. 2011. “Improved Solubilization of Curcumin With a Microemulsification Formulation”. The Annals of the University Dunarea De Jos of Galati. Fascicle VI - Food Technology 35 (2), 46-55. https://www.gup.ugal.ro/ugaljournals/index.php/food/article/view/3519.
Issue
Vol 35 No 2 (2011)
Section
ORIGINAL ARTICLES

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