Study regarding the toxicological activity of some JWH synthetic cannabinoids

  • Mădălina Manuela Coman “Dunarea de Jos“ University of Galati
  • Steluţa Gosav “Dunarea de Jos“ University of Galati
  • Mirela Praisler “Dunarea de Jos“ University of Galati
DOI: https://doi.org/10.35219/ann-ugal-math-phys-mec.2018.1.04
Keywords: JWH synthetic cannabinoids, toxicity, AM1 semi-empirical quantum method

Abstract

In the last years, the synthetic cannabinoids have become popular recreational drugs of abuse because of their psychoactive properties. It is known that some JWH synthetic cannabinoids are even more toxic than their natural counterpart, i.e. cannabis (tetrahydrocannabinol, THC). For this reason, their acute toxic effects may even lead to death under certain circumstances. The aim of the research presented in this paper was to compute different toxicity measures for some of the newest JWH synthetic cannabinoids, by using dedicated software packages. The same toxicity measures have also been determined for THC, which was chosen as standard compound. For this purpose, the geometries of the molecules have been optimized by using the AM1 semi-empirical quantum method. The results of a comparative analysis of toxicities of synthetic and natural cannabinoids are presented.

Author Biographies

Mădălina Manuela Coman, “Dunarea de Jos“ University of Galati

Department of Chemistry, Physics and Environment Corresponding, "Dunarea de Jos" University of Galati, Romania

Steluţa Gosav, “Dunarea de Jos“ University of Galati

Department of Chemistry, Physics and Environment Corresponding, "Dunarea de Jos" University of Galati, Romania

Mirela Praisler, “Dunarea de Jos“ University of Galati

Department of Chemistry, Physics and Environment Corresponding, "Dunarea de Jos" University of Galati, Romania

Published
2018-06-10
How to Cite
Coman, M., Gosav, S. and Praisler, M. (2018) “Study regarding the toxicological activity of some JWH synthetic cannabinoids”, Analele Universității ”Dunărea de Jos” din Galați. Fascicula II, Matematică, fizică, mecanică teoretică / Annals of the ”Dunarea de Jos” University of Galati. Fascicle II, Mathematics, Physics, Theoretical Mechanics, 41(1), pp. 25-32. doi: https://doi.org/10.35219/ann-ugal-math-phys-mec.2018.1.04.
Issue
Vol 41 No 1 (2018)
Section
Articles

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