Effect of 5,4'-dihydroxy-3,6,7,8-tetramethoxyflavone and 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone on mitochondrial function in living K562 and K562/adr cancer cells

  • Jittraporn Chaipratet Faculty of Associated Medical Sciences, Chiang Mai University
  • Montree Tungjai Faculty of Associated Medical Sciences, Chiang Mai University
Keywords: 5,4′-dihydroxy-3,6,7,8-tetramethoxyflavone (WP279), 5,3′-dihydroxy-3,6,7,8,4′-pentamethoxyflavone (WP283), mitochondrial membrane potential, spectrofluorescence technique

Abstract

In the previously study we reported speciation of methoxyflavone including 5,4'-dihydroxy-3,6,7,8-tetramethoxyflavone (WP279) and 5,3'-dihydroxy-3,6,7,8,4'-penta methoxyflavone (WP283) in a physiological solution and their anticancer property. The objective of this study was to determine the effect of 5,4'-dihydroxy-3,6,7,8-tetramethoxyflavone and 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone on mitochondrial membrane potential in drugsensitive, K562 and drug-resistance, K562/adr cancer cell lines by using spectrofluorescence technique. The result shows that WP279 and WP283 slightly increased the mitochondrial membrane potential in K562 and K562/adr due to the concentration.

Published
2011-03-02
How to Cite
1.
Chaipratet J, Tungjai M. Effect of 5,4’-dihydroxy-3,6,7,8-tetramethoxyflavone and 5,3’-dihydroxy-3,6,7,8,4’-pentamethoxyflavone on mitochondrial function in living K562 and K562/adr cancer cells. Innovative Romanian Food Biotechnology [Internet]. 2Mar.2011 [cited 2May2024];(8):8-2. Available from: https://www.gup.ugal.ro/ugaljournals/index.php/IFRB/article/view/3367
Issue
No 8 (2011)
Section
Articles

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